Nfl 2025 Week 2 Predictions. Lines, spreads and betting trends for every game, from vegas insider senior reporter patrick. Plus, the biggest issue on offense for every team.

There are some big favorites across the nfl’s week 2 slate of games, including eight games with a line of at least six points or more. The sports illustrated team gives their picks for all 16 games set to take place in week 2 of the 2025 nfl season.